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Futhermore, GSH was found to reduce ERp57 rapidly at physiological concentrations in vitro , and biotinylated glutathione formed mixed disulphides with ERp57, confirming earlier work showing that glutathione forms a mixed disulphide with ERp57 in intact cells (Fratelli et al , 2002)

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In particular, Trp321 of HGF packs against a short -helix between strand A and B of the fifth blade of c-MET I-SEMA as well as a short loop that connects strand C and D of the sixth blade of c-MET-SEMA

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